-Exacerbated Insulin Resistance: High testosterone can worsen IRS-1 dysfunction, amplifying hyperglycemia risks in conditions where insulin is already compromised.-Elevated Energy Demands: Increased muscle mass raises ATP requirements, potentially outstripping capacity in mitochondrial disorders (e.g., MELAS) or fatty acid oxidation defects.-mTORC1 Overdrive: Suppression of autophagy can be especially harmful in lysosomal storage disorders (e.g., Gaucher disease). Here, IRS1 is linked to Insulin resistance.