GH1 and Insulin resistance: -Elevated FFAs: Increased FFA flux can overwhelm defective β-oxidation in mitochondrial disorders (e.g., VLCAD and LCHAD deficiencies).-Hyperglycemia Risk: GH-induced insulin resistance may exacerbate hyperglycemia in disorders with compromised gluconeogenesis (e.g., glycogen storage diseases).-Mitochondrial Overload: Excess FFAs burden dysfunctional mitochondria, raising oxidative stress and risk of metabolic crises.