Moreover, in the context of prediabetes, which can precede the onset of diabetic symptoms and is associated with an increased risk of atherosclerosis, extracellular vesicles and microRNAs have been found to be involved in the progression of atherosclerosis, with hyperglycemia facilitating the production of extracellular vesicles that carry specific proteins like ROS-producing NADPH oxidase and LDL-scavenging CD36, as well as microRNAs that promote inflammation and hematopoiesis [6]. The gene discussed is FMO5; the disease is atherosclerosis.