BRCA1 and breast carcinoma: BRCA1 and BRCA2 are linked to multiple genes that affect the suppression of homologous recombinational repair (HDR) and lead to breast cancer development by promoting cell proliferation, mitotic aberrations, and genomic instability, as shown in the signaling pathway in Figure 5B. Second, genes co-expressed with SLC25A16 are involved in “Pro-oncogenic action of androgen receptor (p = 2.114 × 10−04)”, “development positive regulation of WNT/Beta catenin signaling in the nucleus (p = 2.957 × 10−04)”, and “transport clathrin-coated vesicle cycle (p = 3.380 × 10−04)” (Figure S6A and Table S6).