Given its pivotal role in gene regulation, dysregulation of VDR signaling has been implicated in a range of pathological conditions, including rickets, psoriasis, renal osteodystrophy, and several autoimmune disorders such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease [29,30]. The gene discussed is VDR; the disease is rheumatoid arthritis.