Concerning this, Miura K et al., using hepatocyte-specific Pten-deficient [Pten(Δ) (hep)] mice models exhibiting steatohepatitis followed by HBLC onset (including HCC)], generated Pten(Δ) (hep)/Tlr4(-−/−) mutant mice and investigated the role of macrophages using reconstitution of bone marrow (BM)-derived cells, chemical depletion of macrophages, and isolated macrophages [18]. The gene discussed is TLR4; the disease is hepatocellular carcinoma.