The authors, by assessing TREM-2 expression in liver tissues of two independent cohorts of patients with HCC, comparing it with control liver samples, and performing in vitro studies with hepatic stellate cells (HSCs) and HCC spheroids, highlighted an upregulation of TREM-2 expression in human HCC tissue, also evidencing conditioned media from HSCs overexpressing TREM-2-inhibited HCC spheroid growth through attenuated Wnt/β-catenin ligand secretion [23]. This evidence concerns the gene TREM2 and hepatocellular carcinoma.