CD8A and neoplasm: As a vicious circle, in turn, these cytokines interfere with apoptotic processes by engaging the JAK-STAT3 and Phosphatidylinositol 3-Kinase (PI3K) pathways, promoting cell survival and potentially leading to cell immortalization [76], as well as creating a pro-tumor microenvironment where the reduced function of CD8+ T cells and recruitment of natural killer T (NKT) cells favor tumor progression via fostering immune escape [78].