Regarding this, Zhe et al., in a study performed on Huh-7 HCC cells, initially demonstrated in vitro the role of extracellular HSP70-peptide complexes in promoting the proliferation of HCC cells via the TLR2/Mitogen-activated Protein Kinase (MAPK) pathway [21]. The gene discussed is WNK2; the disease is hepatocellular carcinoma.