In parallel to the instauration of such “pro-cancerogenic” scenarios (i.e., liver fibrosis and cirrhosis), where liver injury-induced hepatic cell regeneration favors per se malignancy onset, a direct role of TLR (TLR-4 and TLR-2, overall) activation in HCC pathogenesis has been hypothesized and evaluated in different studies [18,19,20,21]. The gene discussed is TLR4; the disease is hepatocellular carcinoma.