Regarding this, Zhe et al., in a study performed on Huh-7 HCC cells, initially demonstrated in vitro the role of extracellular HSP70-peptide complexes in promoting the proliferation of HCC cells via the TLR2/Mitogen-activated Protein Kinase (MAPK) pathway [21]. This evidence concerns the gene TLR2 and hepatocellular carcinoma.