IL6 and cholangiocarcinoma: Focusing on the same IL-6 pathway, in the presence of the enhanced intestinal relative abundance of Ruminococcaceae, Jia et al. reported higher levels of further secondary BAs, including glycochenodeoxycholic acid (GCDA), among others [taurocholic acid (TA), glycodeoxycholic acid (GDA), tauroursodeoxycholic acid (TUDCA), and taurodeoxycholic acid (TDA)], preceding a decreased concentration of chenodeoxycholic acid (CDA) and increased serum levels of IL-6 in CC patients presenting vascular invasion [54].