AVP and myocardial ischemia: Apart from the postulated mechanism of the AVP-mediated protective effect on coronary blood flow, one might also speculate that cardiac ischemia may induce AVP release due to impaired cardiac contractility and reduced cardiac output, which in turn may result in a drop in blood pressure, stimulation of arterial baroreceptors and activation of the autonomous nervous system (ANS), thereby modulating AVP secretion.