NLRP3 and type 2 diabetes mellitus: Additionally, candidalysin stimulates the activation of the NOD-, leucine-rich repeat (LRR)-, and pyrin domain-containing protein 3 (NLRP3) inflammasome, which is a key regulator in inflammatory processes associated with metabolic disorders, including obesity, type 2 diabetes (T2DM), and nonalcoholic fatty liver disease (NAFLD) [47].