IL1B and osteoarthritis: The pathogenesis of osteoarthritis is associated with multiple factors, including sustained inflammatory stimulation, oxidative stress, and abnormal mechanical stress, which interfere with the anabolism and catabolism of cartilage matrix by modulating the synthesis of cartilage matrices (e.g., collagen and proteoglycans) and matrix‐degradation‐related enzymes (e.g., matrix metalloproteinases).[26, 27, 28] In this study, we used IL1‐β to model the inflammatory microenvironment in the pathogenesis of osteoarthritis.