They found that Apo-E4 iPSC-derived neurons, astrocytes, and microglia-like cells recapitulated AD-related phenotypes at multiple levels, and the conversion of Apo-E4 to Apo-E3 in brain cell types derived from sporadic AD iPSCs was sufficient to mitigate multiple Alzheimer’s disease-related pathologies [191]. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.