Co-ultraPEALut attenuates BCCAo-induced memory impairment. It inhibits the NF-κB activation by blocking IκB-α degradation, reducing proinflammatory markers (COX-2, iNOS), and decreasing oxidative stress (nitrotyrosine production). It inhibited apoptosis by decreasing Bax and increasing Bcl2 expression. It also exerts a neuroprotection effect on hippocampal neurons by increasing BDNF and NT-3 expression. This evidence concerns the gene NFKBIA and memory impairment.