HNF4α exerts an inhibitory effect on EMT through its effect on the Wnt/β-catenin signaling pathway via the upregulation of E-cadherin, along with the downregulation of β-catenin and Vimentin, which collectively contribute to the suppression of tumor growth and metastasis in HCC [19,33]. The gene discussed is CDH1; the disease is hepatocellular carcinoma.