TIGAR and cancer: In addition, they tried to establish a correlation between TIGAR expression and 18F-FDG PET/CT imaging parameters in patients with clear cell RCC, knowing that 18F-fluorodeoxyglucose positron emission tomography/computerized tomography [18F-FDG PET/CT] is one of the most important functional imaging techniques used for tumor diagnosis, metastasis detection, and staging in various cancers [66,67].