Our observation of reduced basement membrane vessel sheathing after introduction of exogenous LRG1 is in line with our previous finding of increased collagen IV coverage in tumours in Lrg1−/− mice [24], and could be due to LRG1 decreasing pericyte coverage and disrupting the close apposition of endothelial cells and pericytes. This evidence concerns the gene LRG1 and neoplasm.