We now show that stem cell-reprogramming events initiated by Oct4 and Sox2 induce a mesenchymal transition in GBM cells characterized by the activation of TGFBR2 signaling (Figure 1 and Figure 2) which, in turn, mediates transcriptome changes resembling a Treg state (Figure 3 and Figure S1). Here, TGFBR2 is linked to glioblastoma.