In turn, in the case of lung adenocarcinoma, a set of 10 genes and their genetic variants associated with chemotherapy resistance has been identified (namely, PLEK2, TFAP2A, KIF20A, S100P, GDF15, HSPB8, SASH1, WASF3, LAMA3 and TCN1). This evidence concerns the gene GDF15 and lung adenocarcinoma.