This could be because children exposed to malaria may show a distinct immune response profile with elevated levels of IgG4 antibodies compared to individuals exposed to the malaria parasite, potentially due to the absence of malaria stimulation which favors the production of IgG4, while other IgG subclasses like IgG1 and IgG3, which are more crucial for fighting malaria, are produced in lower amounts [16]. This evidence concerns the gene IGHG3 and malaria.