AKT1 and breast cancer: Genipin, derived from the cape jasmine plant, was found to inhibit BC augmentation in vivo and induce apoptosis by hindering the PI3K/AKT pathway and activating Bax and cytochrome C. Parthenolide, a sesquiterpene lactone, inhibits proliferation and leads to apoptosis and G1-phase arrest in BC cell lines, by PARP induction and downregulation of Bcl-2 [161].