BIRC5 and neoplasm: NF-κΒ also increases the manifestation of anti-apoptotic genes, including survivin, the cellular inhibitor of apoptosis protein 1 and 2 (cIAP-1/2), and the linked inhibitor of apoptosis protein (XIAP) [69], and is implicated in the overexpression of cyclooxygenase 2 (COX-2) in normal and tumor cells.