KLK3 and posterior cortical atrophy: According to the 2014 International Society of Urologic Pathology (ISUP) guidelines, HR-PCa is defined by one or more of the following criteria: an initial prostate-specific antigen (PSA) level > 20 ng/mL, clinical T stage (cT) ≥ 3a, or grade group (GG) ≥ 4 [3].