CAD and metabolic disease: Among these metabolic disorders, CAD (Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase) deficiency, also known as early infantile epileptic encephalopathy-50 (EIEE-50) or alternative title, developmental and epileptic encephalopathy 50 (DEE50, #OMIM 61645), stands out due to its severe and progressive nature [6].