Histological examination confirmed an infiltrative glial lesion (immunoreaction positive for GFAP and negative for OLIG2 in tumor cells), with high cellularity, severe atypia with diffuse pleomorphism, increased mitotic figures (10 mitoses for 10 HPF), diffuse necrosis, and microvascular proliferation was also observed. The gene discussed is GFAP; the disease is neoplasm.