PIK3CA and breast cancer: For example, the Oncotype DX test (21 genes) and MammaPrint (70 genes) help tailor radiation therapy in breast cancer, genetic mutations in KEAP1/NFE2L2/STK11/PIK3CA are linked to radiation resistance in lung cancer, while tumor mutational burden (TMB) predicts a better response to postoperative radiotherapy in non-small cell lung cancer.