Sema3C has recently been studied as a novel biomarker in Hepatocellular carcinoma (HCC), where NRP1 and Integrin Beta1 (ITGβ1) act as functional receptors of Sema3C which activates Serine threonine Kinase (AKT)/GLI Family Zinc Finger 1 (Gli1)/c-Myc signaling pathways leading to tumor initiation [91]. Here, GLI1 is linked to hepatocellular carcinoma.