NRP1 and cancer: On the other hand, Sema3F can interact with NRP1 and reduce the growth of metastatic activity in colorectal carcinoma cells by modifying the integrin αvβ3 region [61] Sema3G’s role in cancer and signaling is less known, except that it plays a crucial role in binding to NRP2 and has been identified as a prognostic marker in glioma cells [62].