It has been reported that the NRP1 expression increases within the CD8+ T cell compartment of the Peripheral blood-derived CD8+ T cells from patients with head and neck squamous cell carcinoma and advanced skin malignancies, and it was correlated with the reduced size of the memory CD8+ T cell pool, poor disease outcome and decrease responsiveness in Immune check blockade (ICB) [105]. Here, CD8A is linked to head and neck squamous cell carcinoma.