HIF-1α expression varies among glioblastoma grade, while HIF-1α expression is mainly located in the cytosol in low-grade gliomas (slow growing), contrasting to high-grade (faster growing), where HIF-1α is distinctively strong in the neighboring areas of necrosis, mostly found in nuclei [4,13,17]. The gene discussed is HIF1A; the disease is glioblastoma.