In a post-stroke context, it modulates microglial signaling pathways (AMPK, SIRT1, SOCS1), promotes M2 polarization, enhances astrocytic energy support by activating AMPK and inhibiting GSK-3β, reduces oxidative stress, and improves oligodendrocyte survival, collectively supporting post-stroke brain homeostasis [131]. The gene discussed is SOCS1; the disease is stroke disorder.