Furthermore, Liu et al. reviewed two decades of research on anti-ischemic stroke drugs targeting the PI3K/Akt pathway, highlighting its role in regulating inflammation, oxidative stress, apoptosis, autophagy, and vascular homeostasis, and emphasizing the growing interest in natural compounds—such as flavonoids, quinones, alkaloids, and terpenoids—in stroke therapy [63] (Figure 2). Here, AKT1 is linked to Stroke.