Neither the spike protein nor ACE2 could be co-immunoprecipitated with STX6 (Fig. S1A and B), whereas colocalization of endogenous STX6 with SARS-CoV-2 spike and N protein was observed 1 h post-infection (Fig. 1E and F), suggesting the proximity of STX6 to endocytic viral particles. This evidence concerns the gene ACE2 and infection.