Consistent with this hypothesis, the formation of double-stranded RNA (dsRNA), an intermediate product of viral replication and a surrogate marker for the entry of SARS-CoV-2 genomic RNA into the host cytosol, was increased in STX6 knockdown cells (Fig. 3F), with substantial dsRNA foci observed in approximately 20% of STX6 knockdown cells compared to about 15% of control cells at 30 min post-infection. This evidence concerns the gene STX6 and infection.