In Alzheimer's disease (AD), asymptomatic amyloid‐positive females show better clinical functioning despite comparable hippocampal atrophy and temporal lobe glucose metabolism,2 and greater tau burden3 compared to males; yet, they show a hastened rate of cognitive decline,4, 5 brain atrophy,6, 7 and functional progression once becoming symptomatic.5 Here, MAPT is linked to Mental deterioration.