EIF5 and colorectal cancer: More recently, work by Sato et al. (2019), showed that the balance of c-MYC proteoforms could be tipped in favour of the AUG-initiated isoform by the oncogenic protein, 5MP1 (eukaryotic initiation factor 5 (eIF5)-mimic protein) that competes with eIF5 [18] and promotes malignancy in colorectal cancer by translational reprogramming [19].