The SCF ubiquitin ligase substrate recognition subunit F-box/WD repeat-containing protein 7, FBXW7, is a well-known tumour suppressor, initiating the ubiquitination and subsequent degradation of many cell cycle-regulated proteins, including oncogenes such as CCNE1(cyclin E), MYC and RICTOR [114–116]. This evidence concerns the gene CCNE1 and neoplasm.