This is likely functional, as one of the substrate recognition/activator subunits of the APC/C that can recognize this motif, CDH1/FZR1, is a SOX2 binding partner [139], and because for CDC20 (the other D box-binding activator subunit), a CDC20-APC/SOX2 signalling axis has been proposed to control some key biological properties of glioblastoma stem cells [140]. This evidence concerns the gene CDC20 and glioblastoma.