Taken together, these data indicate that BCL-2 overexpression leads to a reduced rRNA synthesis rate irrespective of the TP53 mutational status in DLBCL cell lines; however, in a TP53 WT background (SUDHL-5 cell line), these changes translate into weak activation of the RP-MDM2-P53 axis, leading to minor changes in cell proliferation and cell cycle. Here, MDM2 is linked to diffuse large B-cell lymphoma.