Conversely, the overexpression of endothelial CYP2J2 preserves the distribution of endothelial tight junctions and adherens junctions in an ANXA1-dependent manner, thus safeguarding the integrity of the BRB and shielding retinal ganglion cells from loss following ischemia-reperfusion injury (Zhao et al., 2022). This evidence concerns the gene CYP2J2 and ischemia.