FDX1 and cancer: It has been proved that across diverse cancer cell lines, the occurrence of cuproptosis relies on Cu+ causing the oligomerization of lipoylated dihydrolipoamide S-acetyltransferase (DLAT) in the mitochondria, while the reduction of Cu2+ into the more toxic Cu+ and the lipoylation of DLAT depend on FDX1 (Tsvetkov et al., 2022; 2019).