The analysis revealed that the following pathways were upregulated in the hish-risk group: Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Complement and coagulation cascades, Dilated cardiomyopathy, ECM-receptor interaction, Hypertrophic cardiomyopathy, Insulin secretion, Neuroactive ligand-receptor interaction, Protein digestion and absorption, and Salivary secretion. The gene discussed is INS; the disease is Arrhythmogenic right ventricular dysplasia.