TP53 and neoplasm: Our research aligns with previous studies showing that copper induces DNA damage repair and drug resistance (Jin et al., 2022), stabilizes p53 to cause cell cycle arrest and apoptosis in cisplatin-resistant neuroblastoma cells (Zhang et al., 2008), and affects mitochondrial respiration by targeting the pyruvate dehydrogenase complex in the TCA cycle of tumor cells undergoing cuproptosis (Tsvetkov et al., 2022).