CYP19A1 and hyperinsulinemic hypoglycemia, familial, 4: In addition, 7-DHC treatment promoted the proliferation of VDR KO KGN cells and increased ovarian reserve-related mRNA expression of Amh and Amhr2; and estrogen synthesis-related mRNA levels of Hsd17b1 and Cyp19a1. Furthermore, a study has shown that weaned pups of Vdr deficiency mice to a high calcium-containing diet could restore their fertility, whether calcium metabolism affects granulosa cell activity and the effect of calcium on ovarian development deserves further study (Johnson and DeLuca, 2001).