Conversely, CD248 expression is decreased in ten types of cancers, with the correlation between downregulated CD248 expression and BLCA, PRAD, SKCM, OV, and UCEC having been studied (Kuo et al., 2022; Li et al., 2021; Christian et al., 2008; Matthaiou et al., 2022). This evidence concerns the gene CD248 and cancer.