CD248 and neoplasm: CD248 was once thought to be a marker of tumor endothelium and thus named endosialin or tumor endothelial marker 1 (TEM1), however, it is more recognized that CD248 is primarily expressed on stromal fibroblasts, pericytes, vascular smooth muscle cells, and perivascular mesenchymal stem cells, but not endothelial cells (Valdez et al., 2012; Payet et al., 2023; Kapopara et al., 2021).