There are several mechanisms by which CD248 regulates tumor growth and metastasis; for instance, Hsu et al. indicate that CD248 is involved in extracellular matrix (ECM) synthesis by activating the TGF-β signaling pathway (Hong et al., 2024); Zeng et al. demonstrate that CD248 promotes tumor progression by regulating immune cell infiltration or macrophage polarization (Wu et al., 2022). This evidence concerns the gene TGFB1 and neoplasm.