In addition, CD248 is co-expressed on tumor and stromal cells, such as fibroblasts, CD4+ central memory T cells (CD4+ Tcm), CD4+ effector memory T cells (CD4+ Tem), CD8+ Tem, CD8+ Tcm, CD8+ effector T cells, dendritic cells, endothelial cells, granulocytes, macrophages, malignant cells, neutrophils, plasma cells, and smooth muscle cells, suggesting a potential significant role of CD248 in cancer therapy and prognosis (Figures 9C–L; Supplementary Figures S6A–H). This evidence concerns the gene CD4 and cancer.