CD248 and osteosarcoma: As for ADCs, antibody-toxin conjugates such as scFv78-Fc-saporin, and hMP-E−8.3-duocarmycin were effective in killing CD248+ sarcoma cells and eradicating sarcoma and osteosarcoma, respectively (Guo et al., 2018; Capone et al., 2017).