Activated NF-κB, ERK, and AKT can mediate the release of IL-2 and IFN-γ from T cells, and these cytokines can in turn promote T cell proliferation and enhance tumor cell killing (Jorgovanovic et al., 2020; Setrerrahmane and Xu, 2017). The gene discussed is NFKB1; the disease is neoplasm.