Inactivating mutations in the kisspeptin (Kiss1) gene or its receptor (Kiss1r) result in congenital hypogonadotropic hypogonadism and failure to progress through puberty in humans and mice (de Roux et al., 2003; Seminara et al., 2003; Topaloglu et al., 2012). Here, KISS1 is linked to congenital hypogonadotropic hypogonadism.