Serum ANGPTL8 levels were significantly higher (p <0.001) in NAFLD patients (1301.0 ± 617.0 pg/mL) compared to controls (900.0 ± 574.0 pg/mL), even after stratification by obesity or diabetic status. The gene discussed is ANGPTL8; the disease is obesity due to melanocortin 4 receptor deficiency.