When considering ANGPTL8 measurement methods, the subgroup reporting having used the Wuhan EIAab Eliza kit had higher circulating ANGPTL8 levels amongst patients with NAFLD compared to controls with diminished heterogeneity between these four studies (SMD: 0.61, 95% CI: 0.28, 0.94. The gene discussed is ANGPTL8; the disease is metabolic dysfunction-associated steatotic liver disease.