For the seven included studies that were eligible for meta-analysis, the performed random-effects meta-analysis produced a Hedge’s g summary effect of 0.62 (95% CI: 0.28, 0.97), showing that patients with NAFLD/MAFLD had statistically higher circulating ANGPTL8 levels compared to the controls (p = 0.004) (Figure 4). Here, ANGPTL8 is linked to metabolic dysfunction-associated steatotic liver disease.