Additionally, the EPPG proposed the term somatotroph plurihormonal PIT1-positive tumors to define lesions with acromegaly/gigantism that show variable expression of PIT1, GH, TSH and/or PRL and thyrotroph plurihormonal PIT1-positive tumors to define those presenting with central hyperthyroidism. Here, POU1F1 is linked to hyperthyroidism.