BTN2A1, together with BTN3A1, is present on the surface of antigen-presenting cells and cancer cells, and after the internal domain of BTN3A1 binds phosphoantigens, conformational changes in both molecules occur, allowing BTN2A1 to bind to the Vγ9 region of the TCR γδ (186) (Figure 3). This evidence concerns the gene BTN2A1 and cancer.