In terms of cytokine production γδ T cells in SSc exhibit a Th1 polarization, such as IFN-γ production, which contrasts with the Th2 polarization seen in the decidua during pregnancy, where Vδ1 cells inhibit the immune response against the developing fetus (172, 176) This difference suggests the diverse functions of γδ T cells in two distinct conditions, despite the suggestion that γδ T cells interacting with persisting fetal cells post-pregnancy might influence SSc development. Here, IFNG is linked to systemic sclerosis.