The precise characteristics have been explored in prior studies, for example, patients treated with trans-arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) have been found to exhibit lower densities of CD4+/FOXP3+, CD8+, and CD8+/PD-1+ T-cells in the intratumoral area compared to untreated patients (9). This evidence concerns the gene CD4 and hepatocellular carcinoma.