g. Wnt/β -catenin, NF- κ B, TGF- β) in immune cells, fibroblasts and tumor cells (Figures 7H, I) Tumor-associated fibroblasts (CAF) showed high activity in TGF- β and ECM-related pathways, while Treg cells were enriched in IL-10-mediated anti-inflammatory pathways, suggesting unique roles for different cell types in TME regulation. Here, IL10 is linked to neoplasm.