LGR5 and colorectal carcinoma: Following a similar approach, Herpers et al. used a CRC and healthy organoid biobank to identify MCLA-158, a dual-targeting antibody for WNT signaling and EGFR, which effectively inhibited CRC organoid growth with minimal toxicity to benign LGR5+ stem cells using an image base high-content screening approach (Herpers et al., 2022).