The systematic approach demonstrated in this study, with short- and medium-term follow-up, shows that balloon dilation alone in endovascular therapy is a suitable treatment option for venous stenosis unrelated to hemodialysis therapy, but associated with the thrombophilia factor due to the methylenetetrahydrofolate reductase (MTHFR) 677 heterozygous mutation. Here, MTHFR is linked to Rare hereditary thrombophilia.