However, it is possible that VEGF levels may increase predictive capacity in combination with other established markers and risk scores, such as cancer type,6, 7, 35BMI,6, 7, 35and D-dimers,7or alongside other novel biomarkers such as soluble P-selectin.7, 36The study by Posch et al11demonstrated a positive interaction between soluble VEGF levels and D-dimer, indicating that the predictive potential of VEGF might be enhanced in combination with D-dimer, particularly in individuals with high levels of both biomarkers. This evidence concerns the gene VEGFA and cancer.