CD8A and neoplasm: Previous studies have demonstrated that many neutrophils in the tumor microenvironment are affected by CXCR1- and CXCR2-activating ligands produced by tumor cells, which induce the production of NETs to shield immune cells (CD8+ T cells and NK cells) from exposure to tumor cells, thereby preventing tumor cells from being killed by immune cells and facilitating tumor metastasis (27, 44).