One of the crucial roles of E6 protein in cervical cancer development is the degradation of p53, which stimulates cell proliferation and prevents apoptosis, also the degradation of DLG1 or NFX1 hosts, which will lead to upregulation of human telomerase reverse transcriptase (hTERT) and ends in cell immortalisation (Bernard et al. 2011; Doorbar et al. 2012; Sekaric et al. 2008; Van Doorslaer & Burk 2010). This evidence concerns the gene NFX1 and cervical cancer.