For example, Zheng et al. (2020) reported a significant accumulation of pTau in the subgranular cell zone and hilus of the dentate gyrus in both AD patients and mice, with the majority of these pTau-positive cells identified as GABAergic interneurons by co-labeling with GAD67, PV, and somatostatin. This evidence concerns the gene GAD1 and Alzheimer disease.