Results from ordinal regression adjusted for age, sex, vascular risk factors, and stroke subtype, indicate a possible trend between elevated concentrations of ICAM‐1 (OR per 1 SD increase in ICAM‐1 = 1.18; 95% CI:0.89, 1.57), PDGF‐BB (OR per 1 SD increase in PDGF‐BB = 1.17; 95% CI:0.88, 1.57), and E‐selectin (OR per 1 SD increase in E‐Selectin = 1.11; 95% CI:0.86, 1.47) and summary SVD burden observed on MRI, encompassing WMH, PVS, lacunes, and microbleeds (Figure S6 and Table S9). The gene discussed is ICAM1; the disease is stroke disorder.