In logistic regression models adjusted for age, sex, vascular risk factors, and stroke subtype, PDGFRβ and Endo‐1 were associated with decreased odds of lacunes (OR per 1 SD increase in PDGFRβ = 0.71, 95% CI:0.50, 0.99; OR per 1 SD increase in Endo‐1 = 0.71, 95% CI:0.49, 0.99). The gene discussed is PDGFRB; the disease is stroke disorder.