SETD2 and nonpapillary renal cell carcinoma: However, SETD2‐depleted HeLa cells were found to display MSI to a small degree,40 and H3K36me3‐deficient ccRCC cell lines and patients did not show any evidence of MSI,22 probably because of the preferential role of H3K36me3‐mediated MMR in correcting errors and DNA damage occurring during transcription.