CRP, WBC count, total cholesterol, and LDL cholesterol significantly mediated the association between brisk walking pace and any cancer, with proportions of mediation being 6.4% (95% CI 4.4–8.7%), 11.4% (8.4–17.1%), 9.3% (7.1–12.9%), and 8.3% (6.1–11.9%), respectively. Here, CRP is linked to cancer.