COLOTECT is a novel, multi‐target stool DNA‐based non‐invasive test for CRC screening that detects abnormal genes by analyzing Syndecan‐2 (SDC2), Alcohol dehydrogenase iron‐containing 1 (ADHFE1) and Protein phosphatase 2A regulatory subunit B'gamma (PPP2R5C) in DNA methylation. Here, ADHFE1 is linked to colorectal carcinoma.