More importantly, the study tested the combination of SDC2, ADHFE1, and PPP2R5C, which showed an AUC = 0.930 (95% CI: 0.889–0.970) for CRC with a sensitivity of 84.8% and a specificity of 98.0%, and AUC = 0.632 (95% CI 0.542–0.723) for precancerous lesions, with a sensitivity of 31.6% and a specificity of 92.0%, and the study indicated that the combined score of these three microbial markers was more sensitive than FIT in the diagnosis of CRC and advanced adenoma [46]. Here, ADHFE1 is linked to colorectal carcinoma.