TP53 and non-small cell lung carcinoma: Another study, successfully established NSCLC patient and PDX organoid lines, with a KRAS G13C, whereas Naranjo et al. generated KrasG12D mutant, Trp53-deficient (KP) organoids by modeling Kras alteration with p53 loss in wild-type AT2 organoids, using adenovirus-expressed Cre recombinase (Ad5-Cre) [32].